The Organic Cation Transporter 3 (OCT3) Facilitates Fetal Disposition of Metformin during Pregnancy
نویسندگان
چکیده
منابع مشابه
Association between the synonymous variant organic cation transporter 3 (OCT3)-1233G>A and the glycemic response following metformin therapy in patients with type 2 diabetes
Objective(s): Organic cation transporter 3 (OCT3) as a high-capacity transporter contribute to the metabolism of metformin. The present study was conducted to determine the genotype frequencies of the variant OCT3-1233G>A (rs2292334) in patients with newly diagnosed type 2 diabetes (T2D) and its relationship with response to metformin. Materials and Methods: This study included 150 patients wit...
متن کاملLoss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis
Background Organic cation transporters (OCT) are responsible for the uptake of a broad spectrum of endogenous and exogenous substrates. Downregulation of OCT is frequently observed in human hepatocellular carcinoma (HCC) and is associated with a poor outcome. The aim of our current study was to elucidate the impact of OCT3 on hepatocarcinogenesis. Methods Transcriptional and functional loss o...
متن کاملassociation between the synonymous variant organic cation transporter 3 (oct3)-1233g>a and the glycemic response following metformin therapy in patients with type 2 diabetes
objective(s): organic cation transporter 3 (oct3) as a high-capacity transporter contribute to the metabolism of metformin. the present study was conducted to determine the genotype frequencies of the variant oct3-1233g>a (rs2292334) in patients with newly diagnosed type 2 diabetes (t2d) and its relationship with response to metformin. materials and methods: this study included 150 patients wit...
متن کاملThe role of organic cation transporter-3 in methamphetamine disposition and its behavioral response in rats.
Organic cation transporter-3 (OCT3) is expressed in several tissues including the brain. We have previously demonstrated that rats with behavioral sensitization to methamphetamine (METH) increased the brain penetration of METH with decreased expression of OCT3 in brain. Considering the earlier in vitro studies demonstrating that 1) OCT3 could transport dopamine (DA) and 2) the specific transpor...
متن کاملStructure, function, and regional distribution of the organic cation transporter OCT3 in the kidney.
We examined in this study the expression of the potential-sensitive organic cation transporter OCT3 in the kidney. A functionally active OCT3 was cloned from a mouse kidney cDNA library. The cloned transporter was found to be capable of mediating potential-dependent transport of a variety of organic cations including tetraethylammonium. This function was confirmed in two different heterologous ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.891.5